17β-羟基类固醇脱氢酶的最新进展
Recent advances in 17beta-hydroxysteroid dehydrogenases.
作者信息
Prehn Cornelia, Möller Gabriele, Adamski Jerzy
机构信息
Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Genome Analysis Center, Neuherberg, Germany.
出版信息
J Steroid Biochem Mol Biol. 2009 Mar;114(1-2):72-7. doi: 10.1016/j.jsbmb.2008.12.024.
The metabolism of steroids at position 17 is catalysed by a growing number of 17beta-hydroxysteroid dehydrogenases (17beta-HSDs). Several human diseases like breast or prostate cancer, endometriosis,metabolic syndrome and mental diseases were associated with dysfunctions of 17beta-HSDs, which consequently became drug targets. This review will focus on identities of 17beta-HSDs and recent advances in analyses of their physiological roles in steroid and lipid metabolism. It will also address the potential of metabolomics in drug development.
越来越多的17β-羟基类固醇脱氢酶（17β-HSDs）催化甾体17位的代谢。一些人类疾病，如乳腺癌、前列腺癌、子宫内膜异位症、代谢综合征和精神疾病，都与17β-HSDs功能障碍有关，因此17β-HSDs成为了药物靶点。本综述将聚焦于17β-HSDs的特性及其在类固醇和脂质代谢中生理作用分析的最新进展。还将探讨代谢组学在药物开发中的潜力。
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