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威廉姆斯综合征中完整的点光行走者加工:一项脑磁图研究。

Intact point-light walker processing in Williams syndrome: a magnetoencephalography study.

作者信息

Hirai Masahiro, Nakamura Miho, Kaneoke Yoshiki, Kakigi Ryusuke

机构信息

Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan.

出版信息

Neuroreport. 2009 Feb 18;20(3):267-72. doi: 10.1097/wnr.0b013e32832000de.

Abstract

Williams syndrome (WS) is a rare genetic disorder that results in profound spatial cognitive deficits. Several behavioral studies have showed that point-light walker (PLW) perception is intact in children and adults with WS; however, the neural responses underlying PLW perception in adults with WS have not been fully investigated. In this study,we studied an adult with WS by magnetoencephalography. We introduced a novel experimental technique to extract a neuromagnetic response relating to PLW perception, and then evaluated how this response differed from that in normal adults. The peak amplitude and latency of neuromagnetic responses were within 2 SD of the means among normal adults.

摘要

威廉姆斯综合征(WS)是一种罕见的遗传性疾病,会导致严重的空间认知缺陷。多项行为研究表明,患有WS的儿童和成人对光点步行者(PLW)的感知是正常的;然而,WS成年患者中PLW感知背后的神经反应尚未得到充分研究。在本研究中,我们通过脑磁图对一名成年WS患者进行了研究。我们引入了一种新颖的实验技术来提取与PLW感知相关的神经磁反应,然后评估该反应与正常成年人的反应有何不同。神经磁反应的峰值幅度和潜伏期在正常成年人平均值的2个标准差范围内。

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