Department of Mathematics, The Ohio State University, Columbus, OH 43210, USA.
J Theor Biol. 2009 Aug 21;259(4):820-7. doi: 10.1016/j.jtbi.2009.05.001. Epub 2009 May 14.
In this paper we develop a new mathematical model of immunotherapy and cancer vaccination, focusing on the role of antigen presentation and co-stimulatory signaling pathways in cancer immunology. We investigate the effect of different cancer vaccination protocols on the well-documented phenomena of cancer dormancy and recurrence, and we provide a possible explanation of why adoptive (i.e. passive) immunotherapy protocols can sometimes actually promote tumour growth instead of inhibiting it (a phenomenon called immunostimulation), as opposed to active vaccination protocols based on tumour-antigen pulsed dendritic cells. Significantly, the results of our computational simulations suggest that elevated numbers of professional antigen presenting cells correlate well with prolonged time periods of cancer dormancy.
在本文中，我们开发了一种新的免疫治疗和癌症疫苗接种的数学模型，重点研究了抗原呈递和共刺激信号通路在癌症免疫学中的作用。我们研究了不同的癌症疫苗接种方案对癌症休眠和复发的已有文献记载的现象的影响，并对为什么有时采用（即被动）免疫疗法方案实际上可能促进肿瘤生长而不是抑制肿瘤（一种称为免疫刺激的现象），而不是基于肿瘤抗原脉冲树突状细胞的主动疫苗接种方案提供了可能的解释。重要的是，我们的计算模拟结果表明，专业抗原呈递细胞数量的增加与癌症休眠时间的延长密切相关。
