丙型肝炎感染中的端粒捕获
Telomere capture in hepatitis C infection.
作者信息
Goldberg-Bittman Lilach, Amiel Aliza, Hadary Ruth, Fejgin Moshe D, Quitt Miriam, Kitay-Cohen Yona
机构信息
Genetic Institute, Meir Hospital, Kfar Saba 44281, Israel; Faculty of Life Science, Bar-Ilan University, Ramat Gan, Israel.
出版信息
Cancer Genet Cytogenet. 2009 Jun;191(2):63-6. doi: 10.1016/j.cancergencyto.2009.01.013.
Broken chromosomes can acquire new telomeres by "telomere capture" (TC), and it has become possible to investigate the terminus in cytogenetically visible telomere rearrangements. The TC phenomenon was observed in malignant conditions. We evaluated the TC rate in hepatitis C virus (HCV) patients compared to non-Hodgkin's lymphoma patients, as well as relative to a control group. For this purpose, we used two Cytocell probes, 15qter and 13qter. Higher TC rates were found in the three study groups relative to the control group. Our results showed that HCV patients have some of the components that can initiate the cascade of events leading to malignancies.
断裂的染色体可通过“端粒捕获”（TC）获得新的端粒，并且已经能够在细胞遗传学上可见的端粒重排中研究染色体末端。在恶性疾病中观察到了TC现象。我们评估了丙型肝炎病毒（HCV）患者与非霍奇金淋巴瘤患者相比以及相对于对照组的TC率。为此，我们使用了两种Cytocell探针，15qter和13qter。相对于对照组，在三个研究组中发现了更高的TC率。我们的结果表明，HCV患者具有一些能够引发导致恶性肿瘤的一系列事件的成分。
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