Tao Hong-miao, Chen Guo-zhong
School of Medicine, Jinhua College of Profession and Technology, Jinhua , Zhejiang Province, China.
Neurosci Res. 2009 Jul;64(3):311-6. doi: 10.1016/j.neures.2009.04.001. Epub 2009 Apr 10.
Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of ischemic stroke, but data from published studies with individually low statistical power are conflicting. To evaluate the role of eNOS gene polymorphisms in ischemic stroke, we considered all available studies in a meta-analysis. Case-control studies evaluating the association between the G894T, 4b/a polymorphisms and ischemic stroke were searched in MEDLINE, EMBASE, HuGEnet, CBMdisc and CNKI up to December 2008. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) from random- and fixed-effect models were calculated. Data were available for 5516 cases and 6150 controls from 18 studies. We found that homozygosity for the 4a allele of the eNOS gene was not associated with increase in the risk of ischemic stroke (OR, 1.67; 95% CI, 0.81-3.45). A marginal association was observed for homozygosity for the 894T allele with ischemic stroke (OR, 1.14; 95% CI, 0.99-1.31). This analysis provides strong evidence that the eNOS 4b/a gene polymorphisms is not associated with ischemic stroke, the G894T polymorphisms might be associated with ischemic stroke. Further research is warranted to clarify the relevance of G894T polymorphisms to ischemic stroke.
内皮型一氧化氮合酶（eNOS）基因多态性可能会影响缺血性中风的风险，但已发表的统计功效较低的研究数据存在冲突。为了评估eNOS基因多态性在缺血性中风中的作用，我们在一项荟萃分析中纳入了所有可用的研究。截至2008年12月，在MEDLINE、EMBASE、HuGEnet、CBMdisc和CNKI中检索了评估G894T、4b/a多态性与缺血性中风之间关联的病例对照研究。计算了随机效应模型和固定效应模型的合并比值比（OR）及其95%置信区间（CI）。18项研究提供了5516例病例和6150例对照的数据。我们发现，eNOS基因4a等位基因的纯合性与缺血性中风风险增加无关（OR，1.67；95%CI，0.81 - 3.45）。观察到894T等位基因纯合性与缺血性中风之间存在边缘关联（OR，1.14；95%CI，0.99 - 1.31）。该分析提供了强有力的证据，表明eNOS 4b/a基因多态性与缺血性中风无关，G894T多态性可能与缺血性中风有关。有必要进行进一步研究以阐明G894T多态性与缺血性中风的相关性。
