脾脏对恶性疟原虫细胞黏附特性的调节作用。

Spleen modulation of cytoadherence properties of Plasmodium falciparum.

作者信息

Munasinghe Anjanie, Ileperuma Manjula, Premawansa Gayani, Handunnetti Shiroma, Premawansa Sunil

机构信息

Malaria Research Unit, Department of Parasitology, Faculty of Medicine, University of Colombo, Sri Lanka.

出版信息

Scand J Infect Dis. 2009;41(6-7):538-9. doi: 10.1080/00365540902971195.

DOI:10.1080/00365540902971195

PMID:19449257

Abstract

Cytoadherence to CD36 and ICAM-1 and var gene expression of P. falciparum parasites from a splenectomized patient were studied. These parasites lacked cytoadherence and showed expression of a non-coding cDNA sequence. Hence the spleen's modulation of parasite cytoadherence by mechanisms that affect the parasite's surface antigen expression is suggested.

摘要

对一名脾切除患者的恶性疟原虫寄生虫与CD36和ICAM-1的细胞黏附以及var基因表达进行了研究。这些寄生虫缺乏细胞黏附，并显示出一种非编码cDNA序列的表达。因此，提示脾脏通过影响寄生虫表面抗原表达的机制对寄生虫细胞黏附进行调节。