Keymer A E, Tarlton A B
Department of Zoology, University of Oxford.
Parasitology. 1991 Aug;103 Pt 1:121-6. doi: 10.1017/s0031182000059369.
An experiment was designed to investigate aspects of the population dynamics of acquired immunity to Heligmosomoides polygyrus in laboratory mice. The influence of host strain (CBA or NIH), rate of exposure (5 or 40 L3/mouse/2 weeks) and diet (3 or 16% protein w/w) on the population dynamics of repeated infection and the response to a standard challenge infection were investigated. The time delay between the end of the period of repeated infection and the subsequent challenge (between 1 and 24 weeks) had no effect on worm recovery. The effects of both exposure and diet were significant and similar whether assessed on the basis of the dynamics of repeated infection or response to challenge: low rates of exposure and low dietary protein were both associated with low levels of acquired immunity. Mouse strain was the most important determinant of worm recovery after challenge, but had no significant effect on the degree to which parasite population growth was constrained by acquired immunity during repeated infection. It is suggested that both CBA and NIH mice raise immune responses which act on parasite survival, but that only NIH mice raise responses operative against larval establishment.
设计了一项实验来研究实验室小鼠对多房棘球绦虫获得性免疫的种群动态方面。研究了宿主品系（CBA或NIH）、暴露率（5或40条L3/小鼠/2周）和饮食（3%或16%蛋白质，重量/重量）对重复感染种群动态以及对标准攻击感染反应的影响。重复感染期结束与随后攻击之间的时间延迟（1至24周）对虫体恢复没有影响。无论是基于重复感染动态还是对攻击的反应进行评估，暴露和饮食的影响都是显著且相似的：低暴露率和低饮食蛋白质都与低水平的获得性免疫相关。小鼠品系是攻击后虫体恢复的最重要决定因素，但对重复感染期间获得性免疫对寄生虫种群生长的限制程度没有显著影响。研究表明，CBA和NIH小鼠都会产生作用于寄生虫存活的免疫反应，但只有NIH小鼠会产生作用于幼虫定植的反应。
