Wurm Frederik, Klos Johannes, Räder Hans Joachim, Frey Holger
Institute of Organic Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, 55099 Mainz, Germany.
J Am Chem Soc. 2009 Jun 17;131(23):7954-5. doi: 10.1021/ja9019148.
Linear-hyperbranched, heterobifunctional alpha,omega(n) telechelic block copolymers consisting of a linear poly(ethylene glycol) (PEG) chain and a hyperbranched polyglycerol (PG) block have been prepared in five steps, using a protected amino-functional initiator. The polyfunctionality omega(n) (OH groups) can be adjusted by the degree of polymerization (DP(n)) of the polyglycerol block. Subsequent introduction of a single biotin unit by amidation in alpha-position permitted noncovalent bioconjugation with avidin.
由线性聚乙二醇（PEG）链和超支化聚甘油（PG）嵌段组成的线性-超支化、异双功能α,ω(n) 遥爪嵌段共聚物，已通过五步反应制备而成，使用了一种受保护的氨基官能引发剂。多官能度ω(n)（羟基）可通过聚甘油嵌段的聚合度（DP(n)）进行调节。随后通过在α位酰胺化引入单个生物素单元，实现了与抗生物素蛋白的非共价生物共轭。
Bioconjug Chem. 2009-4
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