Zhu Yan, Zhang Yanping, Li Yin
Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Appl Microbiol Biotechnol. 2009 Jun;83(4):597-610. doi: 10.1007/s00253-009-2034-4. Epub 2009 May 23.
Lactic acid bacteria (LAB) are a heterogeneous group of bacteria contributing to various industrial applications, ranging from food and beverage fermentation, bulk and fine chemicals production to pharmaceuticals manufacturing. Genome sequencing is booming; hitherto, 25 genomes of LAB have been published and many more are in progress. Based on genomic content of LAB, this review highlights some findings related to applications revealed by genomics and functional genomics analyses. Finally, this review summarizes mathematical modeling strategies of LAB in the context of genomics, to further our understanding of industrial related features.
乳酸菌(LAB)是一类具有多样性的细菌,在各种工业应用中发挥着作用,涵盖食品和饮料发酵、大宗和精细化学品生产以及制药制造等领域。基因组测序发展迅速;迄今为止,已公布了25个乳酸菌基因组,还有更多正在测序中。基于乳酸菌的基因组内容,本综述重点介绍了基因组学和功能基因组学分析所揭示的与应用相关的一些发现。最后,本综述总结了基因组学背景下乳酸菌的数学建模策略,以加深我们对工业相关特性的理解。