吸烟和外源性物质代谢酶的多态性是否会影响膀胱肿瘤的组织学分期和分级？

Do smoking and polymorphisms in xenobiotic metabolizing enzymes affect the histological stage and grade of bladder tumors?

作者信息

Ouerhani S, Rouissi K, Marrakchi R, Riadh Ben Slama M, Sfaxi M, Ayed M, Chebil M, Elgaaied Ab

机构信息

Laboratoire de Génétique, d'Immunologie et de Pathologies Humaines, Faculté des Sciences de Tunis El-Mannar-I, 2092 Tunis, Tunisie.

出版信息

Bull Cancer. 2009 May;96(5):E23-9. doi: 10.1684/bdc.2009.0872.

DOI:10.1684/bdc.2009.0872

PMID:19467981

Abstract

Cigarette smoking and genetic susceptibility are the two factors most closely associated with bladder cancer development. This study sought to determine the effect of smoking and genetic polymorphisms in xenobiotic metabolizing enzymes on the histological stage and grade of bladder tumors in Tunisian patients. A total of 97 patients with urothelial cell carcinomas were examined with respect to smoking status, NAT2 (N-acetyltransferase 2), GSTM1 and GSTT1 (glutathione S-transferase Mu 1 and teta 1) genotypes distribution. Our data have reported that tobacco; NAT2, GSTM1 and GSTT1 genotypes were not associated with bladder tumor stage. When we studied the superficial bladder tumor group, we have shown that in smokers tobacco was associated with the development of low-grade tumors. Conversely, non-smoker patients carrying altered NAT2 genotypes were with a 3.67-fold increased risk of developing superficial high-grade tumors (P = 0.02; RR = 3.67; 95% CI: [1.40-9.62]).

摘要

吸烟和遗传易感性是与膀胱癌发生最密切相关的两个因素。本研究旨在确定吸烟和外源性代谢酶基因多态性对突尼斯患者膀胱肿瘤组织学分期和分级的影响。共对97例尿路上皮细胞癌患者的吸烟状况、NAT2（N-乙酰转移酶2）、GSTM1和GSTT1（谷胱甘肽S-转移酶Mu 1和Theta 1）基因型分布进行了检测。我们的数据表明，烟草、NAT2、GSTM1和GSTT1基因型与膀胱肿瘤分期无关。当我们研究浅表性膀胱肿瘤组时，我们发现吸烟者中烟草与低级别肿瘤的发生有关。相反，携带改变的NAT2基因型的非吸烟患者发生浅表性高级别肿瘤的风险增加3.67倍（P = 0.02；RR = 3.67；95%CI：[1.40 - 9.62]）。