Gawaz Meinrad, Geisler Tobias
Nat Rev Cardiol. 2009 Jun;6(6):391-2. doi: 10.1038/nrcardio.2009.76.
Dual antiplatelet therapy with aspirin and clopidogrel is effective in limiting adverse coronary thromboischemic events in most patients undergoing coronary stenting. However, platelet reactivity to clopidogrel is variable and stent thrombosis can occur suddenly and unexpectedly in up to 3% of patients. Is responsiveness to clopidogrel an indicator of risk of post-treatment thromboischemic events?
阿司匹林和氯吡格雷联合抗血小板治疗对大多数接受冠状动脉支架置入术的患者在限制不良冠状动脉血栓缺血事件方面是有效的。然而,血小板对氯吡格雷的反应性存在差异,高达3%的患者可能会突然意外地发生支架血栓形成。对氯吡格雷的反应性是否是治疗后血栓缺血事件风险的一个指标?