Varela Aguilar J M, Sánchez-Román J, Castillo Palma M J, Bravo-Ferrer J
Unidad de Colagenosis, Departamento de Medicina Interna, Hospital Universitario Virgen del Rocio Sevilla.
Rev Clin Esp. 1991 Jul;189(3):125-8.
Diffuse lung hemorrhage (DLH) is a rare complication of systemic lupus erythematosus (SLE). We observed lung abnormalities in 72 cases (39.5%) out of 182 SLE patients. DLH was confirmed in 3 male patients with steroids and cyclophosphamide was favorable in all cases but there was a recurrence in one case. None of the patients died due to this condition, although artificial live maintaining measures were necessary in one patient. DLH is more difficult to suspect of in the absence of hemoptysis and when there is not a previous diagnosis of SLE. However, the decrease in hematocrit and serum complement levels in a patient with bilateral lung infiltrate can be orientative. DLH must be included in the differential diagnosis of bilateral alveolar infiltrates in SLE inspite its low frequency, since it is a condition with e high mortality rate but with possible cure if it is promptly diagnosed.
弥漫性肺出血（DLH）是系统性红斑狼疮（SLE）的一种罕见并发症。我们在182例SLE患者中观察到72例（39.5%）存在肺部异常。3例男性患者确诊为DLH，使用类固醇和环磷酰胺治疗，所有病例病情均好转，但有1例复发。尽管有1例患者需要采取人工维持生命的措施，但无一例患者因该疾病死亡。在没有咯血且既往未诊断为SLE的情况下，更难怀疑DLH。然而，双侧肺部浸润患者的血细胞比容和血清补体水平降低可能具有提示意义。尽管DLH发病率较低，但在SLE患者双侧肺泡浸润的鉴别诊断中必须考虑到它，因为它是一种死亡率高但如果能及时诊断则有可能治愈的疾病。
