Hwang Hyun Seok, Boluyt Marvin O, Converso Kimber, Russell Mark W, Bleske Barry E
Division of Kinesiology, Laboratory of Molecular Kinesiology, University of Michigan, Ann Arbor, Michigan, USA.
Pharmacotherapy. 2009 Jun;29(6):639-48. doi: 10.1592/phco.29.6.639.
To determine the effects of hawthorn (Crataegus oxycantha) on left ventricular remodeling and function in pressure overload-induced heart failure in an animal model.
Randomized, parallel, dose-ranging animal study.
University research facility.
Seventy-four male Sprague-Dawley rats; 44 were included in the final analysis.
Rats underwent a sham operation or aortic constriction. Rats subjected to the sham operation were treated with vehicle (10% agar-agar), and those subjected to aortic constriction were treated with vehicle or hawthorn (C. oxycantha special extract WS 1442) 1.3, 13, or 130 mg/kg for 5 months.
Rats and their hearts were weighed, and echocardiographic measurements were performed at baseline and at 2, 3, 4, and 5 months after aortic constriction. Protein expression for markers of fibrosis and for atrial natriuretic factor was also measured. Aortic constriction increased the left ventricular:body weight ratio by 53% in vehicle-treated rats; Hawthorn treatment did not significantly affect the aortic constriction-induced increase in this ratio. Left ventricular volumes and dimensions at systole and diastole significantly increased 5 months after aortic constriction compared with baseline in rats given vehicle (> 20% increase, p<0.05) but not in those given hawthorn 130 mg/kg (< 10% increase). After aortic constriction, the velocity of circumferential shortening significantly decreased in the vehicle group but not in the medium- or high-dose groups. In the aortic constriction-vehicle group, the induced increases in messenger RNA expression for atrial natriuretic factor (approximately 1000%) and fibronectin (approximately 80%) were significantly attenuated by high-dose hawthorn treatment by approximately 80% and 50%, respectively.
Hawthorn treatment exhibited modest beneficial effects on cardiac remodeling and function during long-term, pressure overload-induced heart failure in rats.
在动物模型中确定山楂（Crataegus oxycantha）对压力超负荷诱导的心力衰竭中左心室重构和功能的影响。
随机、平行、剂量范围动物研究。
大学研究机构。
74只雄性Sprague-Dawley大鼠；最终分析纳入44只。
大鼠接受假手术或主动脉缩窄。接受假手术的大鼠用赋形剂（10%琼脂）治疗，接受主动脉缩窄的大鼠用赋形剂或山楂（C. oxycantha特殊提取物WS 1442）1.3、13或130 mg/kg治疗5个月。
称重大鼠及其心脏，并在主动脉缩窄后基线以及2、3、4和5个月时进行超声心动图测量。还测量了纤维化标志物和心房利钠因子的蛋白表达。在接受赋形剂治疗的大鼠中，主动脉缩窄使左心室与体重之比增加了53%；山楂治疗对主动脉缩窄引起的该比例增加没有显著影响。与基线相比，接受赋形剂的大鼠在主动脉缩窄5个月后，收缩期和舒张期的左心室容积和尺寸显著增加（增加>20%，p<0.05），但接受130 mg/kg山楂治疗的大鼠则未出现这种情况（增加<10%）。主动脉缩窄后，赋形剂组的圆周缩短速度显著降低，而中剂量或高剂量组则未降低。在主动脉缩窄-赋形剂组中，高剂量山楂治疗分别使心房利钠因子（约1000%）和纤连蛋白（约80%）的信使核糖核酸表达诱导增加显著减弱了约80%和50%。
在大鼠长期压力超负荷诱导的心力衰竭期间，山楂治疗对心脏重构和功能表现出适度的有益作用。
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