他克莫司软膏：一种治疗恒河猴（猕猴属）局限性特应性皮炎的新型有效局部治疗方法。
Tacrolimus ointment: a novel and effective topical treatment of localized atopic dermatitis in a rhesus macaque (Macaca mulatta).
作者信息
Torreilles Stéphanie L, Luong Richard H, Felt Stephen A, McClure Diane E
机构信息
Department of Comparative Medicine Stanford University, School of Medicine, Stanford, California, USA.
出版信息
J Am Assoc Lab Anim Sci. 2009 May;48(3):307-11.
An adult, male, rhesus macaque presented with pruritus and a focal, exudative, inflamed, erythematous skin lesion of approximately 2 cm in diameter on the ventral aspect of the mandible. The lesion resolved after 10 d of treatment with 1% chlorhexidine solution and triple-antibiotic ointment. However, the skin lesion subsequently recurred several times over a 2-mo period. A punch biopsy was performed, and histological changes were most consistent with a diagnosis of atopic dermatitis. Treatment with topical tacrolimus ointment, an immunosuppressive drug, proved successful in the resolution of all clinical signs after 4 mo. According to a literature review, this article is the first report of the use of tacrolimus ointment as a topical treatment of atopic dermatitis in a rhesus macaque.
一只成年雄性恒河猴，下颌腹侧出现瘙痒，有一个直径约2厘米的局灶性、渗出性、炎症性红斑皮肤病变。用1%洗必泰溶液和三联抗生素软膏治疗10天后病变消退。然而，在2个月内皮肤病变随后又复发了几次。进行了打孔活检，组织学变化最符合特应性皮炎的诊断。使用免疫抑制药物外用他克莫司软膏治疗，4个月后所有临床症状均成功消退。根据文献综述，本文是关于他克莫司软膏外用治疗恒河猴特应性皮炎的首次报道。
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