Motta Mario M S, Coblentz Jacqueline, Fernandes Bruno F, Burnier Miguel N
Federal University of the State of Rio de Janeiro, UNIRIO, Rio de Janeiro, Brazil.
Ophthalmic Res. 2009;42(2):87-9. doi: 10.1159/000220601. Epub 2009 May 27.
BACKGROUND/AIMS: To evaluate and compare cardiovascular effects (blood pressure and heart rate) of phenylephrine 2.5% versus phenylephrine 10%, and compare pupil diameter before and after instillation of eyedrops.
A total of 58 patients scheduled for funduscopy were dilated with either phenylephrine 2.5% and tropicamide 1% (group 0, n = 29 patients, 58 eyes) or phenylephrine 10% and tropicamide 1% (group 1, n = 29 patients, 58 eyes). Only one drop per eye of each drug was administered. In both groups, pupil diameter, blood pressure and heart rate were measured before and 40 min after eyedrop instillation.
We did not observe significant changes in blood pressure or heart rate. Mean pupil diameter in group 0, before the instillation of eyedrops, was 3.51 mm and, in group 1, 2.66 mm. After medication, mean values were 7.38 mm in group 0 and 7.42 mm in group 1. Mean variation was 3.87 mm in group 0 and 4.76 mm in group 1 (p < 0.001).
Our results corroborate the finding that one single drop of either 2.5 or 10% phenylephrine is safe and, when 1% tropicamide is combined, satisfactory pupil dilation is achieved.
背景/目的：评估并比较2.5%去氧肾上腺素与10%去氧肾上腺素对心血管系统的影响（血压和心率），并比较滴眼前后的瞳孔直径。
共有58例计划进行眼底检查的患者，分别用2.5%去氧肾上腺素和1%托吡卡胺（0组，n = 29例患者，58只眼）或10%去氧肾上腺素和1%托吡卡胺（1组，n = 29例患者，58只眼）进行散瞳。每种药物每只眼仅滴一滴。两组均在滴眼前后测量瞳孔直径、血压和心率。
我们未观察到血压或心率有显著变化。0组滴眼前平均瞳孔直径为3.51mm，1组为2.66mm。用药后，0组平均值为7.38mm，1组为7.42mm。0组平均变化为3.87mm，1组为4.76mm（p < 0.001）。
我们的结果证实了以下发现：单独一滴2.5%或10%的去氧肾上腺素是安全的，并且与1%托吡卡胺联合使用时，可实现令人满意的瞳孔散大。
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