胶原蛋白受体 DDR2 在心脏早期发育过程中表达。
The collagen receptor DDR2 is expressed during early cardiac development.
机构信息
Department of Cell, Biology and Anatomy, University of South Carolina, School of Medicine, Columbia, South Carolina, USA.
出版信息
Anat Rec (Hoboken). 2010 May;293(5):762-9. doi: 10.1002/ar.20922.
Abstract
Discoidin Domain Receptor 2 (DDR2) is a receptor tyrosine kinase which has been shown to regulate cell migration upon binding its ligand, collagen. Expression studies determined that DDR2 mRNA and protein are present in the atrioventricular canal during epithelial-mesenchymal transformation (EMT) and the receptor is expressed in both activated endothelial and migrating mesenchymal cells in vivo.
摘要
Discoidin Domain Receptor 2 (DDR2) 是一种受体酪氨酸激酶，已被证明在与其配体胶原结合后可调节细胞迁移。表达研究确定，在房室管的上皮-间充质转化（EMT）过程中存在 DDR2 mRNA 和蛋白，并且在体内的活化内皮细胞和迁移的间充质细胞中均表达该受体。
相似文献
1
The collagen receptor DDR2 is expressed during early cardiac development.
Anat Rec (Hoboken). 2010 May;293(5):762-9. doi: 10.1002/ar.20922.
2
Functional BMP receptor in endocardial cells is required in atrioventricular cushion mesenchymal cell formation in chick.
Dev Biol. 2007 Jun 1;306(1):179-92. doi: 10.1016/j.ydbio.2007.03.015. Epub 2007 Mar 16.
3
Molecular basis and functional significance of Angiotensin II-induced increase in Discoidin Domain Receptor 2 gene expression in cardiac fibroblasts.
J Mol Cell Cardiol. 2016 Jan;90:59-69. doi: 10.1016/j.yjmcc.2015.12.004. Epub 2015 Dec 8.
4
Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse.
Am J Physiol Heart Circ Physiol. 2014 Sep 1;307(5):H773-81. doi: 10.1152/ajpheart.00142.2014. Epub 2014 Jul 3.
5
Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2.
J Biol Chem. 2002 Feb 1;277(5):3606-13. doi: 10.1074/jbc.M107571200. Epub 2001 Nov 26.
6
Signaling via the Tgf-beta type I receptor Alk5 in heart development.
Dev Biol. 2008 Oct 1;322(1):208-18. doi: 10.1016/j.ydbio.2008.07.038. Epub 2008 Aug 7.
7
The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis.
Nat Cell Biol. 2013 Jun;15(6):677-87. doi: 10.1038/ncb2743. Epub 2013 May 5.
8
Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart.
Science. 1999 Mar 26;283(5410):2080-2. doi: 10.1126/science.283.5410.2080.
9
May the fibrosis be with you: Is discoidin domain receptor 2 the receptor we have been looking for?
J Mol Cell Cardiol. 2016 Feb;91:201-3. doi: 10.1016/j.yjmcc.2016.01.006. Epub 2016 Jan 7.
10
Discoidin domain receptor 2 is a critical regulator of epithelial-mesenchymal transition.
Matrix Biol. 2011 May;30(4):243-7. doi: 10.1016/j.matbio.2011.03.007. Epub 2011 Apr 6.
引用本文的文献
1
Endothelial-Mesenchymal Transition and Possible Role of Cytokines in Streptozotocin-Induced Diabetic Heart.
Biomedicines. 2025 May 9;13(5):1148. doi: 10.3390/biomedicines13051148.
2
Exploring the Cellular and Molecular Mechanism of Discoidin Domain Receptors (DDR1 and DDR2) in Bone Formation, Regeneration, and Its Associated Disease Conditions.
Int J Mol Sci. 2023 Oct 4;24(19):14895. doi: 10.3390/ijms241914895.
3
Blockage of the adenosine A receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension.
Purinergic Signal. 2024 Apr;20(2):163-179. doi: 10.1007/s11302-023-09952-z. Epub 2023 Jul 5.
4
DDR2 coordinates EMT and metabolic reprogramming as a shared effector of FOXQ1 and SNAI1.
Cancer Res Commun. 2022 Nov;2(11):1388-1403. doi: 10.1158/2767-9764.crc-22-0013. Epub 2022 Nov 9.
5
Defining cardiac cell populations and relative cellular composition of the early fetal human heart.
PLoS One. 2022 Nov 30;17(11):e0259477. doi: 10.1371/journal.pone.0259477. eCollection 2022.
6
Developmental Pathways of Cardiac Fibroblasts.
Cold Spring Harb Perspect Biol. 2020 Apr 1;12(4):a037184. doi: 10.1101/cshperspect.a037184.
7
Redefining the identity of cardiac fibroblasts.
Nat Rev Cardiol. 2017 Aug;14(8):484-491. doi: 10.1038/nrcardio.2017.57. Epub 2017 Apr 24.
8
Myocardial fibroblast-matrix interactions and potential therapeutic targets.
J Mol Cell Cardiol. 2014 May;70:92-9. doi: 10.1016/j.yjmcc.2014.01.008. Epub 2014 Jan 26.
9
Origin, development, and differentiation of cardiac fibroblasts.
J Mol Cell Cardiol. 2014 May;70:2-8. doi: 10.1016/j.yjmcc.2013.11.003. Epub 2013 Nov 11.
10
Discoidin domain receptor tyrosine kinases: new players in cancer progression.
Cancer Metastasis Rev. 2012 Jun;31(1-2):295-321. doi: 10.1007/s10555-012-9346-z.
本文引用的文献
1
A series of normal stages in the development of the chick embryo.
J Morphol. 1951 Jan;88(1):49-92.
2
A three-dimensional tubular scaffold that modulates the osteogenic and vasculogenic differentiation of rat bone marrow stromal cells.
Tissue Eng Part A. 2008 Apr;14(4):491-504. doi: 10.1089/tea.2007.0235.
3
Discoidin domain receptor 2 inhibits fibrillogenesis of collagen type 1.
J Mol Biol. 2006 Sep 1;361(5):864-76. doi: 10.1016/j.jmb.2006.06.067. Epub 2006 Aug 1.
4
Expression of Discoidin Domain Receptor 2 (DDR2) in the developing heart.
Microsc Microanal. 2005 Jun;11(3):260-7. doi: 10.1017/S1431927605050518.
5
Cell biology of cardiac cushion development.
Int Rev Cytol. 2005;243:287-335. doi: 10.1016/S0074-7696(05)43005-3.
6
Organization of fibroblasts in the heart.
Dev Dyn. 2004 Aug;230(4):787-94. doi: 10.1002/dvdy.20095.
7
Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis.
Am J Pathol. 2004 May;164(5):1575-85. doi: 10.1016/S0002-9440(10)63716-9.
8
Molecular markers of cardiac endocardial cushion development.
Dev Dyn. 2003 Dec;228(4):643-50. doi: 10.1002/dvdy.10418.
9
Vitreous induces components of the prostaglandin E2 pathway in human retinal pigment epithelial cells.
Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1767-74. doi: 10.1167/iovs.02-0528.
10
Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2.
J Biol Chem. 2002 Feb 1;277(5):3606-13. doi: 10.1074/jbc.M107571200. Epub 2001 Nov 26.
Zotero 插件