Prié Dominique, Ureña Torres Pablo, Friedlander Gérard
AP-HP, Hôpital Necker-Enfants Malades, Paris, France.
Med Sci (Paris). 2009 May;25(5):489-95. doi: 10.1051/medsci/2009255489.
The kidney is a key player of phosphate balance, it determines serum phosphate levels by coupling phosphate reabsorption in the renal proximal tubule, calcitriol synthesis and consequently intestinal -phosphate absorption. The identification of fibroblast growth factor 23 (FGF23) as a hormone regulating phosphate and calcitriol metabolism has unveiled the mechanisms that coordinate these renal proximal tubule functions. A bone-kidney axis has emerged that controls bone mineralization. Animal model studies have improved our understanding of phosphate homeostasis and revealed the role of the Klotho protein, which is mandatory to FGF23 action. In this review, we detail FGF23 and Klotho implication in physiology and in genetic or acquired disorders. Phosphate ion is involved in vascular and soft tissue calcification and is important for cell proliferation. Disorders of FGF23-klotho axis alter life span and are involved in senescence.
肾脏是磷酸盐平衡的关键调节器官，它通过耦合肾近端小管中的磷酸盐重吸收、骨化三醇合成以及随后的肠道磷酸盐吸收来决定血清磷酸盐水平。成纤维细胞生长因子23（FGF23）作为一种调节磷酸盐和骨化三醇代谢的激素被发现，揭示了协调这些肾近端小管功能的机制。一种控制骨矿化的骨-肾轴已经形成。动物模型研究增进了我们对磷酸盐稳态的理解，并揭示了Klotho蛋白的作用，它是FGF23发挥作用所必需的。在这篇综述中，我们详细阐述了FGF23和Klotho在生理学以及遗传或获得性疾病中的影响。磷酸离子参与血管和软组织钙化，对细胞增殖很重要。FGF23-Klotho轴紊乱会改变寿命并与衰老有关。
