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mRNA和rRNA质量控制的相关机制。

Related mechanisms for mRNA and rRNA quality control.

作者信息

Swisher Kylie D, Parker Roy

机构信息

Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA.

出版信息

Mol Cell. 2009 May 14;34(4):401-2. doi: 10.1016/j.molcel.2009.05.008.


DOI:10.1016/j.molcel.2009.05.008
PMID:19481519
Abstract

In this issue of Molecular Cell, Cole et al. (2009) provide evidence that different defects in rRNA function are recognized by distinct RNA quality control systems, and suggest that a stalled ribosome can trigger either no-go decay of the mRNA or degradation of a nonfunctional 18S rRNA.

摘要

在本期《分子细胞》杂志中,科尔等人(2009年)提供了证据,表明核糖体RNA(rRNA)功能的不同缺陷可被不同的RNA质量控制系统识别,并提出停滞的核糖体可触发信使核糖核酸(mRNA)的无义介导衰变或无功能的18S核糖体RNA的降解。

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Related mechanisms for mRNA and rRNA quality control.

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[3]
A convergence of rRNA and mRNA quality control pathways revealed by mechanistic analysis of nonfunctional rRNA decay.

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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Protecting the proteome: Eukaryotic cotranslational quality control pathways.

J Cell Biol. 2014-2-17

[2]
Whi3, an S. cerevisiae RNA-binding protein, is a component of stress granules that regulates levels of its target mRNAs.

PLoS One. 2013-12-27

[3]
RNA degradation in Saccharomyces cerevisae.

Genetics. 2012-7

[4]
Pathologic effects of RNase-L dysregulation in immunity and proliferative control.

Front Biosci (Schol Ed). 2012-1-1

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