尿S100A1B和S100BB用于预测足月时的缺氧缺血性脑病。

Urinary S100A1B and S100BB to predict hypoxic ischemic encephalopathy at term.

作者信息

Bashir Moataza, Frigiola Alessandro, Iskander Iman, Said Hala Mufeed, Aboulgar Hanna, Frulio Rosanna, Bruschettini Pierluigi, Michetti Fabrizio, Florio Pasquale, Pinzauti Serena, Abella Raul, Mussap Michele, Gazzolo Diego

机构信息

Department of Neonatology, Cairo University, Cairo, Egypt.

出版信息

Front Biosci (Elite Ed). 2009 Jun 1;1(2):560-7. doi: 10.2741/e54.

DOI:10.2741/e54

PMID:19482672

Abstract

Urinary S100A1B and S100BB were measured to detect cases at risk of hypoxic-ischemic encephalopathy (HIE) in asphyxiated newborns. We recruited 42 asphyxiated infants and 63 healthy term neonates. S100A1B and S100BB were measured at first urination (time 0) and at 4 (time 1), 8 (time 2), 12 (time 3), 16 (time 4), 20 (time 5), 24 (time 6), 72 (time 7) hours after birth. 20 infants had no/mild HIE with good prognosis (Group A) and 22 had moderate/severe HIE with a greater risk of neurological handicap (Group B). Urine S100A1B and S100BB levels were significantly (P less than 0.0.01, for all) higher at all monitoring time-points in Group B than Group A and controls, but not between Group A and controls. Both S100A1B and S100BB have great sensitivity and specificity for HIE since their first measurement. In conclusion, S100A1B and S100BB are increased in urine collected from asphyxiated newborns who will develop HIE since first urination, and their measurement may be useful to early predict HIE when monitoring procedures are still of no avail.

摘要

检测窒息新生儿尿液中的S100A1B和S100BB，以发现有缺氧缺血性脑病（HIE）风险的病例。我们招募了42名窒息婴儿和63名健康足月儿。在出生后的首次排尿（时间0）以及出生后4小时（时间1）、8小时（时间2）、12小时（时间3）、16小时（时间4）、20小时（时间5）、24小时（时间6）、72小时（时间7）测量S100A1B和S100BB。20名婴儿无HIE/轻度HIE且预后良好（A组），22名婴儿有中度/重度HIE且神经功能障碍风险更高（B组）。在所有监测时间点，B组尿液中S100A1B和S100BB水平均显著高于A组和对照组（所有P均小于0.001），但A组和对照组之间无差异。自首次测量以来，S100A1B和S100BB对HIE均具有很高的敏感性和特异性。总之，从首次排尿起就将发生HIE的窒息新生儿尿液中S100A1B和S100BB升高，在监测程序仍无济于事时，检测它们可能有助于早期预测HIE。