HLA - A*02等位基因在葡萄牙多发性硬化症患者中的保护作用。
Protective role of the HLA-A*02 allele in Portuguese patients with multiple sclerosis.
作者信息
Silva A M, Bettencourt A, Pereira C, Santos E, Carvalho C, Mendonça D, Costa P P, Monteiro L, Martins B
机构信息
Departamento de Neurologia, Centro Hospitalar do Porto-Hospital de Santo António, Porto, Portugal.
出版信息
Mult Scler. 2009 Jun;15(6):771-4. doi: 10.1177/1352458509104588.
BACKGROUND
Multiple sclerosis (MS) is associated with human leukocyte antigen (HLA) HLA-DRB115. Recent evidence that CD8 T cells are implicated in MS suggests that HLA class I may also contribute. An association of HLA-A02 and A*03 alleles has been described.
OBJECTIVES
We examined the influence of HLA-A02 and HLA-A03 in Portuguese patients with MS, independently of HLA-DRB1*15 using a logistic regression model.
CONCLUSIONS
DRB115 increased the risk of developing MS and HLA-A02 decreased the risk. A03 had no effect. To analyze if HLA-A02 association was independent from DRB1*15, an interaction between these two alleles was introduced in the model; no significant interaction was found.
背景
多发性硬化症（MS）与人类白细胞抗原（HLA）-DRB115相关。最近有证据表明CD8 T细胞与MS有关，这表明HLA I类分子可能也有作用。已有关于HLA-A02和A*03等位基因关联的描述。
目的
我们使用逻辑回归模型，在不考虑HLA-DRB115的情况下，研究HLA-A02和HLA-A*03对葡萄牙MS患者的影响。
结论
DRB115增加了患MS的风险，而HLA-A02降低了风险。A03没有影响。为分析HLA-A02的关联是否独立于DRB1*15，在模型中引入了这两个等位基因之间的相互作用；未发现显著的相互作用。
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