一项关于白癜风患者耳声发射和抑制效应的研究。
A study on otoacoustic emissions and supression effects in patients with vitiligo.
机构信息
Departamento de Fonoaudiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo.
出版信息
Braz J Otorhinolaryngol. 2009 Jan-Feb;75(1):111-5. doi: 10.1016/s1808-8694(15)30841-7.
UNLABELLED
Vitiligo is a skin disease characterized by absence of melanin due to melanocytes destruction.
AIM
to study the incidence of hearing alterations in patients with vitiligo.
METHOD
prospective audiological evaluation, transient-evoked otoacoustic emission recordings and study the effects of suppression in 24 patients with vitiligo. Their ages ranged from 15 to 45 years.
RESULTS
21 patients (87.5%) had normal audiometry; 2 had unilateral hearing loss in the high frequencies and 1 had cochlear moderate hearing loss in the left ear. Of these 21 subjects, 66.7% had no otoacoustic emissions, suggesting cochlear dysfunction. Only 7 patients had otoacoustic emissions present in all frequencies (29.2%) and 17 (70.8%) did not have them, and the highest rate of no otoacoustic emissions happened in the right ear of males. Regarding the suppression study, 6 subjects failed, all of them were females, and their left ears were the most affected.
CONCLUSION
the findings show that patients with vitiligo, particularly males, have a greater predisposition to cochlear dysfunction, especially in the right ear. As far as the suppression effect was concerned, there was a greater alteration in the female efferent system, particularly in the left ear. Hearing alterations did not vary as far as age is concerned, type of vitiligo and time of disease progression.
目的
研究白癜风患者听力改变的发生率。
方法
对 24 例白癜风患者进行前瞻性听力学评估、瞬态诱发耳声发射记录，并研究抑制作用。患者年龄 15～45 岁。
结果
21 例（87.5%）听力正常；2 例高频单侧听力损失，1 例左耳耳蜗中度听力损失。21 例受试者中，66.7%无耳声发射，提示耳蜗功能障碍。仅 7 例在所有频率均存在耳声发射（29.2%），17 例（70.8%）无耳声发射，且右耳男性无耳声发射的发生率最高。关于抑制研究，6 例失败，均为女性，且左耳受影响最大。
结论
研究结果表明，白癜风患者，尤其是男性，更易发生耳蜗功能障碍，尤其是右耳。就抑制作用而言，女性传出系统的改变更大，尤其是左耳。听力改变与年龄、白癜风类型和疾病进展时间无关。
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