Sarkar-Tyson Mitali, Smither Sophie J, Harding S V, Atkins Timothy P, Titball Richard W
Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 OJQ, UK.
Vaccine. 2009 Jul 16;27(33):4447-51. doi: 10.1016/j.vaccine.2009.05.040. Epub 2009 May 31.
Burkholderia pseudomallei and Burkholderia mallei are gram-negative bacilli that are the causative agents of melioidosis and glanders, respectively. Both humans and animals are susceptible to both diseases. There is currently no vaccine available for the prevention of disease. We report the protective efficacy of heat-inactivated Burkholderia thailandensis, B. mallei or B. pseudomallei cells as vaccines against murine melioidosis and glanders. Immunisation with heat-inactivated B. pseudomallei cells provided the highest levels of protection against either melioidosis or glanders. These studies indicate the longer term potential for heat-inactivated bacteria to be developed as vaccines against melioidosis and glanders.
类鼻疽伯克霍尔德菌和鼻疽伯克霍尔德菌是革兰氏阴性杆菌，分别是类鼻疽和鼻疽的病原体。人和动物对这两种疾病均易感。目前尚无预防疾病的疫苗。我们报告了热灭活的泰国伯克霍尔德菌、鼻疽伯克霍尔德菌或类鼻疽伯克霍尔德菌细胞作为疫苗对小鼠类鼻疽和鼻疽的保护效力。用热灭活的类鼻疽伯克霍尔德菌细胞免疫可提供针对类鼻疽或鼻疽的最高水平保护。这些研究表明热灭活细菌作为抗类鼻疽和鼻疽疫苗具有长期开发潜力。
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