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选择性5-羟色胺再摄取抑制剂类抗抑郁药与新生儿持续性肺动脉高压

SSRI antidepressants and persistent pulmonary hypertension in newborns.

出版信息

Prescrire Int. 2008 Aug;17(96):156.

Abstract

(1) The list of adverse effects of selective serotonin reuptake inhibitor (SSRI) antidepressants in pregnant women and their newborns continues to grow; (2) It was already known that, when taken towards the end of pregnancy, SSRIs could cause spontaneously resolving neonatal disorders, particularly neurological problems; (3) A case-control study has shown an association between maternal exposure to SSRI antidepressants after the 20th week of pregnancy and neonatal persistent pulmonary hypertension, with a 6-fold increase in the risk. Another study has provided similar results; (4) Diagnosis of depression must be made with care during pregnancy, and it should be remembered that not all patients with depression require drug therapy.

摘要

(1) 选择性血清素再摄取抑制剂(SSRI)类抗抑郁药对孕妇及其新生儿的不良反应清单持续增加;(2) 人们已知,在孕期接近尾声时服用SSRI类药物会导致新生儿疾病自然缓解,尤其是神经系统问题;(3) 一项病例对照研究表明,孕妇在妊娠20周后接触SSRI类抗抑郁药与新生儿持续性肺动脉高压之间存在关联,风险增加了6倍。另一项研究也得出了类似结果;(4) 孕期诊断抑郁症时必须谨慎,应记住并非所有抑郁症患者都需要药物治疗。

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