Department of Medical and Molecular Biosciences, University of Technology, Sydney, P.O. Box 123, Broadway, NSW 2007, Australia.
Int J Parasitol. 2009 Sep;39(11):1173-87. doi: 10.1016/j.ijpara.2009.05.007. Epub 2009 Jun 2.
Neospora caninum is a protozoan parasite that causes abortion in cattle around the world. Although the clinical signs of disease in both dogs and cattle have now been recognised for over 20years, treatment and control options are still limited, despite the availability of a commercial vaccine in some countries of the world. The case for an efficacious vaccine has not been convincingly waged by farmers, veterinarians and other members of the agricultural and rural communities. In recent times, however, economic modelling has been used to estimate the industry losses due to Neospora-associated abortion, providing, in turn, the business case for forms of control for this parasite, including the development of vaccines. In this review, we document progress in all areas of the vaccine development pipeline, including live, killed and recombinant forms and the animal models available for vaccine evaluation. In addition, we summarise the main outcomes on the economics of Neospora control and suggest that the current boom in the global dairy industry increases the specific need for a vaccine against N. caninum-associated abortion.
刚地弓形虫是一种引起全世界牛流产的原生动物寄生虫。尽管犬和牛的疾病临床症状已经被认识超过 20 年，但治疗和控制选择仍然有限，尽管在世界上的一些国家有商业化的疫苗。尽管农民、兽医和其他农业和农村社区成员提出了有效的疫苗的情况，但仍没有说服力。然而，最近经济建模已被用于估算因弓形虫相关流产造成的行业损失，从而为控制这种寄生虫的各种形式提供了商业案例，包括疫苗的开发。在这篇综述中，我们记录了疫苗开发管道各个领域的进展，包括活疫苗、死疫苗和重组疫苗，以及可用于疫苗评估的动物模型。此外，我们总结了关于弓形虫控制经济学的主要结果，并指出全球乳制品行业的繁荣增加了对弓形虫相关流产疫苗的具体需求。
