miR-15a 和 miR-16-1 在癌症中的作用、发现和未来展望。

miR-15a and miR-16-1 in cancer: discovery, function and future perspectives.

机构信息

The Lautenberg Center for General and Tumor Immunology, Hebrew University-Hadassah Medical School, Institute for Medical Research Israel-Canada, Ein Karem, P.O. Box 12272, Jerusalem 91120, Israel.

出版信息

Cell Death Differ. 2010 Feb;17(2):215-20. doi: 10.1038/cdd.2009.69. Epub 2009 Jun 5.

DOI:10.1038/cdd.2009.69

PMID:19498445

Abstract

MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors. Expression of these miRNAs inhibits cell proliferation, promotes apoptosis of cancer cells, and suppresses tumorigenicity both in vitro and in vivo. miR-15a and miR-16-1 function by targeting multiple oncogenes, including BCL2, MCL1, CCND1, and WNT3A. Down-regulation of these miRNAs has been reported in chronic lymphocytic lymphoma (CLL), pituitary adenomas, and prostate carcinoma. This review summarizes the discovery, functions, and clinical relevance of these miRNAs in cancer, particularly CLL.

摘要

miRNAs（miRNAs）由 miR-15/16 簇编码，已知其作为肿瘤抑制因子发挥作用。这些 miRNA 的表达抑制细胞增殖，促进癌细胞凋亡，并在体外和体内抑制肿瘤发生。miR-15a 和 miR-16-1 通过靶向多个癌基因，包括 BCL2、MCL1、CCND1 和 WNT3A，发挥作用。已经在慢性淋巴细胞性淋巴瘤（CLL）、垂体腺瘤和前列腺癌中报道了这些 miRNA 的下调。本综述总结了这些 miRNA 在癌症中的发现、功能和临床相关性，特别是在 CLL 中的相关性。