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[脑膜炎球菌的抗溶菌酶活性]

[The antilysozyme activity of meningococci].

作者信息

Bukharin O V, Borisov S D, Ezepchuk Iu V, Kostiukova N N, Usviatsov B Ia, Fan'kovskaia E K

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1991 Jul(7):17-20.

PMID:1950256
Abstract

The antilysozyme activity of 184 meningococcal strains was studied. Such activity was found in all strains within the range 1-25 micrograms/ml, which was due to the heterogeneity of bacterial population. Strains varying in the total level of their lysozyme activity differed in the population structure by this sign. Preparations inhibiting antilysozyme activity could be differentiated according to the character of their action by the method of the population analysis. In the process of phagocytosis the selection of clones with a high level of antilysozyme activity was found to occur. The antilysozyme factor, heat resistant protein with a molecular weight of 10,000-30,000 D, was sensitive to trypsin.

摘要

对184株脑膜炎球菌菌株的抗溶菌酶活性进行了研究。在所有菌株中均发现了1-25微克/毫升范围内的这种活性,这是由于细菌群体的异质性所致。溶菌酶活性总水平不同的菌株在群体结构上以此特征存在差异。抑制抗溶菌酶活性的制剂可通过群体分析方法根据其作用特性进行区分。在吞噬过程中,发现具有高抗溶菌酶活性的克隆会被选择。抗溶菌酶因子是一种分子量为10,000-30,000道尔顿的耐热蛋白,对胰蛋白酶敏感。

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