迈向针对多发性骨髓瘤的有效靶向化疗。
Toward an effective targeted chemotherapy for multiple myeloma.
作者信息
Polson Andrew G, Sliwkowski Mark X
机构信息
Genentech Inc, South San Francisco, California 94080, USA.
出版信息
Clin Cancer Res. 2009 Jun 15;15(12):3906-7. doi: 10.1158/1078-0432.CCR-09-0572. Epub 2009 Jun 9.
Abstract
Antibody-drug conjugates (ADCs), cytotoxic drugs chemically linked to antibodies, provide a means to increase the effectiveness of chemotherapy by targeting the drug to neoplastic cells. Anti-CD138 ADCs show promising preclinical efficacy for the treatment of multiple myeloma; however, the safety aspects of targeting CD138 have yet to be explored.
摘要
抗体药物偶联物（ADCs）是将细胞毒性药物与抗体化学连接而成的，它通过将药物靶向肿瘤细胞，提供了一种提高化疗效果的方法。抗CD138 ADCs在治疗多发性骨髓瘤方面显示出有前景的临床前疗效；然而，靶向CD138的安全性方面尚未得到探索。
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