[2-氰基丙烯酸辛酯粘合剂与缝合术在犬小肠模型伤口闭合中的比较]
[Comparison of 2-octyl cyanoacrylate adhesive and suturing for wound closure in the canine small bowel model].
作者信息
Escalante-Piña Oscar, García-Nieto Gabriela, Hernández-Jasso Alma Rocío, Reyes-Castellanos Liliana, Flores-Aragón Mariana, Rivera-Cruz Jose María
机构信息
Departamento de Anatomía Humana y Laboratorio de Adiestramiento e Investigación Quirúrgica, Escuela Médico Militar, México, D. F., Mexico.
出版信息
Cir Cir. 2009 Mar-Apr;77(2):121-5.
OBJECTIVE
We undertook this study to evaluate 2-octyl cyanoacrylate (2OCA) glue and suture for wound closure in the small bowel.
METHODS
This was a comparative and experimental study. Male and female domestic dogs (n = 10) underwent a 2.0-cm small bowel closure of two wounds. All of these had closure with 2OCA in the first wound. The controls (second wound in the same dog) were closed with suture. Four weeks later the wounds were observed to evaluate the repair.
RESULTS
Wound closure time and macrophage count were lower with the 2OCA glue than in the suture group.
CONCLUSIONS
2OCA glue has the strength to seal a small bowel wound. The inflammatory response to the glue is less than that of the suture at 4 weeks. These properties may make it a suitable material for replacing suture in a small bowel wound.
目的
我们开展本研究以评估2-氰基丙烯酸辛酯（2OCA）胶水和缝线用于小肠伤口闭合的效果。
方法
这是一项对比性实验研究。10只雄性和雌性家犬接受了两个2.0厘米小肠伤口的闭合手术。所有犬的第一个伤口均用2OCA胶水进行闭合。对照组（同一只犬的第二个伤口）用缝线进行闭合。四周后观察伤口以评估修复情况。
结果
与缝线组相比，2OCA胶水的伤口闭合时间和巨噬细胞计数更低。
结论
2OCA胶水有能力封闭小肠伤口。四周时，胶水引起的炎症反应小于缝线。这些特性可能使其成为替代小肠伤口缝线的合适材料。
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