Doros Attila, Nemes Balázs, Fehérvári Imre, Görög Dénes, Gerlei Zsuzsa, Németh Andrea, Hartmann Erika, Deák Akos Pál, Fazakas János, Tóth Szabolcs, Kóbori László
Semmelweis Egyetem, Altalános Orvostudományi Kar, Transzplantációs és Sebészeti Klinika, Budapest.
Orv Hetil. 2009 Jun 28;150(26):1231-4. doi: 10.1556/OH.2009.28607.
Liver transplantation is a routinely used therapeutic choice in the treatment of end stage liver disease. Portal vein stenosis is a rare vascular complication after liver transplantation. We report the interventional radiological management of three cases of portal vein stenosis.
The surgical management of portal vein stenosis can be hazardous for the patient and the transplanted liver in the early post-transplantation period. In general, interventional radiological methods are tolerable for patients and can be safely performed with high success rate. The aim of this report is to analyze the feasibility, the risks and the efficacy of the percutaneous transhepatic self expanding metallic stent placement into the portal vein.
Three of the 396 liver transplantations cases in Budapest developed significant portal vein stenosis. In these cases, ultrasound guided percutaneous transhepatic portal vein puncture with fine needle was performed. The tract was dilated with a coaxial dilator set, and an adequately sized sheath introducer was inserted into the liver parenchyma. Two nitinol and one stainless steel self expanding metallic stent were implanted at the stenotic portal vein anastomoses. The tract was embolized with gelfoam particles (1 case), or coils (1 case). In the third patient no tract embolization was performed.
All treatments were technically successful, without minor or major complications. In two cases the amount of free abdominal fluid decreased significantly, and in the third case the esophageal varicosity regressed. The morphological success was documented with ultrasound and computed tomography examination. Two patients are alive and well after 10 and 39 months of follow up, while the third patient died after one month in multi organ failure.
Percutaneous transhepatic metallic stent placement for the treatment of post-transplantation portal vein stenosis is a safe and effective method.
肝移植是治疗终末期肝病的常规治疗选择。门静脉狭窄是肝移植后罕见的血管并发症。我们报告3例门静脉狭窄的介入放射学治疗。
门静脉狭窄的手术治疗在移植后早期对患者和移植肝脏可能具有危险性。一般来说,介入放射学方法患者可耐受,且能安全实施,成功率高。本报告的目的是分析经皮经肝门静脉置入自膨式金属支架的可行性、风险及疗效。
布达佩斯396例肝移植病例中有3例发生明显门静脉狭窄。对这些病例,采用超声引导下经皮经肝门静脉细针穿刺。用同轴扩张器套装扩张穿刺通道,将合适尺寸的鞘管引入器插入肝实质。在狭窄的门静脉吻合口植入2枚镍钛合金和1枚不锈钢自膨式金属支架。穿刺通道用明胶海绵颗粒(1例)或弹簧圈(1例)栓塞。第3例患者未进行穿刺通道栓塞。
所有治疗在技术上均获成功,无轻微或严重并发症。2例患者腹腔游离液体量显著减少,第3例患者食管静脉曲张消退。超声和计算机断层扫描检查证实形态学上获得成功。2例患者在随访10个月和39个月后存活且情况良好,而第3例患者在1个月后死于多器官功能衰竭。
经皮经肝金属支架置入术治疗移植后门静脉狭窄是一种安全有效的方法。