在麻风病神经病变的谱系中：预示麻风病复发的多灶性炎性神经病变。

On the spectrum of leprosy neuropathies: multifocal inflammatory neuropathy heralding leprosy relapse.

作者信息

Gondim Francisco de Assis A, Thomas Florian P, de Oliveira Gisele Ramos, Pimentel Leonardo Halley C, Bastos Bruno Pamplona Ranieri, de Castro Costa Carlos Maurício

机构信息

Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.

出版信息

Neuromuscul Disord. 2009 Oct;19(10):711-3. doi: 10.1016/j.nmd.2009.05.007. Epub 2009 Jun 23.

DOI:10.1016/j.nmd.2009.05.007

PMID:19553119

Abstract

We report a 52 year-old woman with a past history of lepromatous leprosy (14 years prior to our first evaluation) who presented with progressive weakness and severe arm/leg pain. CSF analysis revealed elevated protein level with normal cell count. Skin and sural nerve biopsy showed no bacilli. Immunomodulatory treatment led to major improvement on clinical, CSF and electrodiagnostic grounds, but after one year of treatment, skin test revealed leprosy relapse. To our knowledge, this is the first report of a multifocal inflammatory neuropathy heralding leprosy relapse. Extended neurological work-up may be important in unexplained neuropathy progression after leprosy treatment.

摘要

我们报告了一名52岁女性，有瘤型麻风病史（在我们首次评估前14年），表现为进行性肌无力和严重的手臂/腿部疼痛。脑脊液分析显示蛋白水平升高而细胞计数正常。皮肤和腓肠神经活检未发现杆菌。免疫调节治疗在临床、脑脊液和电诊断方面带来了显著改善，但治疗一年后，皮肤试验显示麻风复发。据我们所知，这是首例预示麻风复发的多灶性炎性神经病报告。在麻风治疗后不明原因的神经病变进展中，进行全面的神经系统检查可能很重要。