核型正常的II级非典型脉络丛乳头状瘤。
Grade II atypical choroid plexus papilloma with normal karyotype.
作者信息
Brassesco María Sol, Valera Elvis Terci, Becker Aline Paixão, Oliveira Ricardo Santos, Scrideli Carlos Alberto, Machado Hélio Rubens, Tone Luiz Gonzaga
机构信息
Division of Pediatric Oncology, Department of Pediatrics, University of São Paulo, São Paulo, Brazil.
出版信息
Childs Nerv Syst. 2009 Dec;25(12):1623-6. doi: 10.1007/s00381-009-0938-z. Epub 2009 Jun 25.
PURPOSE
Cytogenetic studies of atypical choroid plexus papillomas (CPP) have been poorly described. In the present report, the cytogenetic investigation of an atypical CPP occurring in an infant is detailed.
METHODS
CPP chromosome preparations were analyzed by giemsa-trypsin-banding (GTG-banding) and comparative genome hybridization (CGH).
RESULTS
Conventional karyotype analysis of tumor culture showed a normal chromosome complement. The results were confirmed by CGH, showing normal hybridization patterns for the sample.
CONCLUSIONS
To date, the few atypical CPPs described in the literature have shown disparate cytogenetic information. This is the first report of a normal chromosome complement in atypical CPP. The heterogenic genetic features observed in these small series may reflect the diverse genetic background of choroid plexus tumors in children.
目的
非典型脉络丛乳头状瘤（CPP）的细胞遗传学研究报道较少。在本报告中，详细介绍了对一名婴儿发生的非典型CPP的细胞遗传学研究。
方法
通过吉姆萨-胰蛋白酶显带（GTG显带）和比较基因组杂交（CGH）分析CPP染色体标本。
结果
肿瘤培养物的常规核型分析显示染色体组正常。CGH结果证实了这一点，显示样本的杂交模式正常。
结论
迄今为止，文献中描述的少数非典型CPP显示出不同的细胞遗传学信息。这是关于非典型CPP染色体组正常的首次报道。在这些小样本系列中观察到的异质性遗传特征可能反映了儿童脉络丛肿瘤的不同遗传背景。
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