埃及亚历山大港口咽癌病例生存情况的流行病学研究。

An epidemiological study on survival of oropharyngeal cancer cases in Alexandria, Egypt.

作者信息

Ibrahim N K R, Al Ashakar M S, Gad Z M, Warda M H, Ghanem H

机构信息

Department of Family and Community Medicine, Faculty of Medicine, King Abdul-Aziz University, Jeddah, Saudi Arabia.

出版信息

East Mediterr Health J. 2009 Mar-Apr;15(2):369-77.

PMID:19554984

Abstract

A retrospective cohort study was conducted to determine the 5-year survival and prognostic factors for survival for 407 oropharyngeal cancer cases registered in the 3 main hospitals in Alexandria, Egypt, from 1996-2000. Survival analysis was conducted using Kaplan-Meier curves, and multivariate Cox regression analysis. The overall 5-year survival rate was 30.8%. Multivariate analysis showed that significant prognostic factors for survival were tumour stage (hazard ratio = 2.39; 95% CI: 1.41-11.72), tumour site and patient's age. Secondary prevention of oral cancers can be conducted through examination of the oral cavity to find precancerous and early cancerous lesions and hence improve survival.

摘要

开展了一项回顾性队列研究，以确定1996年至2000年在埃及亚历山大市3家主要医院登记的407例口咽癌病例的5年生存率及生存预后因素。采用Kaplan-Meier曲线和多变量Cox回归分析进行生存分析。总体5年生存率为30.8%。多变量分析显示，生存的显著预后因素为肿瘤分期（风险比=2.39；95%置信区间：1.41-11.72）、肿瘤部位和患者年龄。口腔癌的二级预防可通过口腔检查来发现癌前病变和早期癌性病变，从而提高生存率。