Sui Jun, Gao Wei, Li Xiao-jiang, Ma Jing, Ren Yan-xin, Song Xin, Xiao Chun-jie, Tang Wen-ru
Department of Head and Neck Surgery, Third Hospital Affiliated Kunming Medical University, Yunnan Cancer Reaserch Center, Kunming 650118, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Mar;44(3):227-31.
The aim of this study was to investigate the susceptibility and prognostic implications of the cyclin D1 gene (CCND1) G870A polymorphism to nasopharyngeal carcinomas (NPC) in Han population in Yunnan China.
Two hundred and forty one cases with NPC and 271 matched cancer-free controls were genotyped for the CCND1 G870A polymorphism by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing. The adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated by using unconditional logistic regression model. Overall survival was assessed using univariate and multivariate analyses.
Contrast with homozygous CCND1 G870G, A allele significantly increasing risk of NPC was associated with homozygous A870A (OR = 4.79, 95% CI 2.77 - 8.28, P < 0.001) and heterozygous A870G (OR = 1.72, 95% CI 1.10 - 2.68, P = 0.017). The subjects at least having one CCND1 870A allele had OR of 2.40 (95% CI 1.59 - 3.63, P < 0.001). Furthermore, smoking may increase the risk of developing NPC interacting with CCND1 G870A polymorphism. Kaplan-Meier analysis and Cox regression analysis demonstrated that the five-year survival rate of subjects with AA, AG and GG genotype was 56.2%, 78.5% and 81.4% (AA vs GG, P = 0.003; AA vs AG, P = 0.012; AG vs GG, P = 0.132), but not independent prognostic factor in NPC (P = 0.501).
The CCND1 870A allele is associated with the NPC in Han population in Yunnan China, meanwhile, showed a significant prognosis for those patients.
本研究旨在探讨细胞周期蛋白D1基因（CCND1）G870A多态性对中国云南汉族人群鼻咽癌（NPC）的易感性及预后影响。
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）和测序技术对241例鼻咽癌患者及271例匹配的无癌对照进行CCND1 G870A多态性基因分型。使用无条件逻辑回归模型计算调整后的比值比（OR）和95%置信区间（CI）。采用单因素和多因素分析评估总生存期。
与纯合子CCND1 G870G相比，A等位基因显著增加NPC风险，与纯合子A870A（OR = 4.79，95% CI 2.77 - 8.28，P < 0.001）和杂合子A870G（OR = 1.72，95% CI 1.10 - 2.68，P = 0.017）相关。至少有一个CCND1 870A等位基因的受试者OR为2.40（95% CI 1.59 - 3.63，P < 0.001）。此外，吸烟可能会增加与CCND1 G870A多态性相互作用而发生NPC的风险。Kaplan-Meier分析和Cox回归分析表明，AA、AG和GG基因型受试者的五年生存率分别为56.2%、78.5%和81.4%（AA与GG相比，P = 0.003；AA与AG相比，P = 0.012；AG与GG相比，P = 0.132），但不是NPC的独立预后因素（P = 0.501）。
CCND1 870A等位基因与中国云南汉族人群的鼻咽癌相关，同时，对这些患者显示出显著的预后影响。
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