孕早期筛查中血清标志物的调整。

Adjustment of serum markers in first trimester screening.

作者信息

Lambert-Messerlian Geralyn, Palomaki Glenn E, Canick Jacob A

机构信息

Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, 70 Elm Street, Providence, RI 02903 USA.

出版信息

J Med Screen. 2009;16(2):102-3. doi: 10.1258/jms.2009.009028.

DOI:10.1258/jms.2009.009028

PMID:19564524

Abstract

First trimester combined screening can be performed using maternal serum pregnancy-associated plasma protein A, total human chorionic gonadotropin (hCG) and ultrasound measurement of nuchal translucency at 11-13 weeks of pregnancy. Our objective was to explore the effects of covariates on total hCG in the first trimester. First trimester total hCG levels were significantly increased in twins (median = 1.87 MoM), mildly increased in pregnancies achieved by in vitro fertilization (1.04 MoM) and decreased in smokers (0.80 MoM).

摘要

孕早期联合筛查可在孕11 - 13周时，通过检测孕妇血清妊娠相关血浆蛋白A、总人绒毛膜促性腺激素（hCG）以及超声测量胎儿颈部透明带厚度来进行。我们的目的是探讨协变量对孕早期总hCG的影响。双胎妊娠的孕早期总hCG水平显著升高（中位数 = 1.87倍中位数倍数），体外受精妊娠的总hCG水平轻度升高（1.04倍中位数倍数），而吸烟者的总hCG水平降低（0.80倍中位数倍数）。