干细胞衰老及龛内异常分化。
Stem cell aging and aberrant differentiation within the niche.
作者信息
Choi Jinkuk, Artandi Steven
机构信息
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
出版信息
Cell Stem Cell. 2009 Jul 2;5(1):6-8. doi: 10.1016/j.stem.2009.06.006.
PMID:19570507
Abstract
Stem cells age, but the underlying mechanisms remain unclear. In a recent issue of Cell, Inomata and colleagues (2009) show that DNA damage, a prime suspect in stem cell aging, causes graying and loss of melanocyte stem cells by inducing premature differentiation, without inducing apoptosis or senescence.
摘要
干细胞会衰老，但其潜在机制仍不清楚。在最近一期的《细胞》杂志上，猪俣及其同事（2009年）表明，DNA损伤是干细胞衰老的主要嫌疑因素，它通过诱导过早分化导致黑素细胞干细胞变白和丧失，而不会诱导细胞凋亡或衰老。
Zotero 插件