局部mRNA的平等招募

Egalitarian recruitment of localized mRNAs.

作者信息

Nashchekin Dmitry, St Johnston Daniel

机构信息

Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.

出版信息

Genes Dev. 2009 Jul 1;23(13):1475-80. doi: 10.1101/gad.1821509.

DOI:10.1101/gad.1821509

PMID:19571176

Abstract

Bicaudal-D (Bic-D) and Egalitarian (Egl) are required for the dynein-dependent localization of many mRNAs in Drosophila, but the mRNAs show no obvious sequence similarities, and the RNA-binding proteins that recognize them and link them to dynein are not known. In this issue of Genes & Development, Dienstbier and colleagues (pp. 1546-1558) present evidence that the elusive RNA-binding protein is Egl itself. As well as linking mRNA to dynein, they show that Egl also activates dynein motility by binding Bic-D and the dynein light chain.

摘要

双尾-D（Bic-D）和平等蛋白（Egl）是果蝇中许多mRNA依赖动力蛋白进行定位所必需的，但这些mRNA没有明显的序列相似性，识别它们并将它们与动力蛋白连接的RNA结合蛋白尚不清楚。在本期《基因与发育》中，丁斯特比尔及其同事（第1546 - 1558页）提供证据表明，难以捉摸的RNA结合蛋白就是Egl本身。除了将mRNA与动力蛋白连接外，他们还表明Egl通过结合Bic-D和动力蛋白轻链来激活动力蛋白的运动。