弥漫性大B细胞淋巴瘤和伯基特淋巴瘤。

Diffuse large B-cell lymphomas and burkitt lymphoma.

作者信息

de Leval Laurence, Hasserjian Robert Paul

机构信息

Department of Pathology, CHU Sart Tilman, Institute of Pathology, Liège, Belgium.

出版信息

Hematol Oncol Clin North Am. 2009 Aug;23(4):791-827. doi: 10.1016/j.hoc.2009.04.004.

DOI:10.1016/j.hoc.2009.04.004

PMID:19577170

Abstract

Diffuse large B-cell lymphomas (DLBCLs) and Burkitt lymphoma (BL) account for the majority of aggressive lymphomas in adults and children. DLBCLs exhibit marked biological heterogeneity and variable clinical presentation and clinical course. Conversely, BL is genetically relatively homogeneous but associated with variable clinicopathological features. In this article, the authors summarize the recent advances pertaining to these B-cell neoplasms, following the latest World Health Organization classification and focusing on changes introduced since the previous edition. These changes include the addition of variants and subgroups of DLBCLs and "borderline" categories for high-grade B-cell neoplasms that show features intermediate between DLBCL and classical Hodgkin lymphoma, or between DLBCL and BL. In particular, the diagnostic and therapeutic problems related to neoplasms with features intermediate between DLBCL and BL will be discussed.

摘要

弥漫性大B细胞淋巴瘤（DLBCL）和伯基特淋巴瘤（BL）占成人和儿童侵袭性淋巴瘤的大多数。DLBCL表现出显著的生物学异质性以及多样的临床表现和临床病程。相反，BL在基因上相对同质，但与多种临床病理特征相关。在本文中，作者按照世界卫生组织的最新分类，总结了这些B细胞肿瘤的最新进展，并重点关注自上一版以来的变化。这些变化包括增加了DLBCL的变体和亚组，以及为高级别B细胞肿瘤设置的“临界”类别，这些肿瘤表现出介于DLBCL与经典霍奇金淋巴瘤之间，或介于DLBCL与BL之间的特征。特别是，将讨论与具有介于DLBCL和BL之间特征的肿瘤相关的诊断和治疗问题。