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与奥氮平相关的阴茎异常勃起。

Priapism associated with olanzapine.

作者信息

Hosseini S H, Polonowita A K

机构信息

Department of Psychiatry, Behavioral Science and Psychiatric Research Center, Zare Psychiatry Hospital, Mazandaran Medical Sciences University, K.M5 Sari-Neka High Way, Sari, Mazandaran, Post Cod 48171-19164, Iran.

出版信息

Pak J Biol Sci. 2009 Jan 15;12(2):198-200. doi: 10.3923/pjbs.2009.198.200.

Abstract

Priapism is a rare but serious adverse effect of psychotropic drugs where antipsychotic agents were implicated in 15 to 26% of priapism associated with medications. Among atypical antipsychotic, clozapine, risperidone and olanzapine have been reported to be associated with the condition. The patient was a 24-years-old male referred to the OPD Clinic at Zare Psychiatry Hospital in 2007 with symptoms of delusion of control, delusion of persecution, delusion of somatic and auditory hallucination, for the last year. He had priapism following the use of olanzapine. Serotonin-Dopamine Antagonist (SDA) should be proscribed with care became of this rare yet serious complication, especially in cases with previous history of priapism following the use of psychotropic drugs.

摘要

阴茎异常勃起是精神药物罕见但严重的不良反应,其中15%至26%的药物相关性阴茎异常勃起与抗精神病药物有关。在非典型抗精神病药物中,据报道氯氮平、利培酮和奥氮平与该病有关。该患者为一名24岁男性,于2007年因过去一年出现被控制妄想、被害妄想、躯体妄想和幻听症状转诊至扎雷精神病医院门诊。他在使用奥氮平后出现了阴茎异常勃起。由于这种罕见但严重的并发症,应谨慎使用5-羟色胺-多巴胺拮抗剂(SDA),尤其是在有精神药物使用后阴茎异常勃起病史的病例中。

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