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老年人合理用药:对两种筛查工具的调查,即考虑诊断与否的《Beers标准》以及爱尔兰初级保健中用于识别老年人不当用药情况的《老年人改善用药工具》。

Appropriate prescribing in the elderly: an investigation of two screening tools, Beers criteria considering diagnosis and independent of diagnosis and improved prescribing in the elderly tool to identify inappropriate use of medicines in the elderly in primary care in Ireland.

作者信息

Ryan C, O'Mahony D, Kennedy J, Weedle P, Barry P, Gallagher P, Byrne S

机构信息

Pharmaceutical Care Research Group, School of Pharmacy, University College Cork, Cork, Ireland.

出版信息

J Clin Pharm Ther. 2009 Aug;34(4):369-76. doi: 10.1111/j.1365-2710.2008.01007.x.

Abstract

BACKGROUND

Elderly patients are particularly vulnerable to inappropriate prescribing, with increased risk of adverse drug reactions and consequently higher rates of morbidity and mortality. A large proportion of inappropriate prescribing is preventable by adherence to prescribing guidelines, suitable monitoring and regular medication review. As a result, screening tools have been developed to help clinicians improve their prescribing.

OBJECTIVES

To compare identification rates of inappropriate prescribing in elderly patients in primary care using two validated screening tools: Beers' criteria and improved prescribing in the elderly tool (IPET); to calculate the net ingredient cost (NIC) per month (euro) of the potentially inappropriate medicines in this population of patients.

METHOD

A consecutive cohort of 500 patients 65 years of age and over were recruited prospectively from primary care over a 6 month period in a provincial town in Ireland. Patients' medical records (electronic and paper) were screened and all relevant information concerning current illnesses and medications was recorded on a standardized data collection form to which Beers' criteria [considering diagnosis (CD) and independent of diagnosis (ID)] and IPET tools were applied. The NIC was calculated from an edition of the Irish monthly index of medical specialities published concurrently with the data collection.

RESULTS

Beers' criteria identified a total of 69 medicines that were prescribed inappropriately (eight CD and 61 ID) in 65 patients (13%), costing euro824.88 per month while IPET identified 63 potentially inappropriate medicines in 52 (10.4%) patients costing euro381.28 per month.

CONCLUSIONS

Potentially inappropriate medications are prescribed in a significant proportion of elderly people in primary care, with significant economic implications.

摘要

背景

老年患者特别容易出现不适当的处方用药情况,药物不良反应风险增加,进而导致更高的发病率和死亡率。通过遵循处方指南、进行适当监测和定期药物审查,很大一部分不适当的处方用药情况是可以预防的。因此,已开发出筛查工具来帮助临床医生改进其处方用药。

目的

使用两种经过验证的筛查工具——《Beers标准》和《老年人用药改进工具》(IPET),比较初级保健中老年患者不适当处方用药的识别率;计算该患者群体中潜在不适当药物每月的净成分成本(NIC,单位:欧元)。

方法

在爱尔兰一个省城,于6个月期间从初级保健机构中前瞻性招募了500名65岁及以上的患者。对患者的病历(电子和纸质)进行筛查,并将所有有关当前疾病和用药的相关信息记录在标准化的数据收集表上,同时应用《Beers标准》(考虑诊断情况[CD]和不考虑诊断情况[ID])和IPET工具。NIC根据与数据收集同时发布的一版爱尔兰医学专科月度指数进行计算。

结果

《Beers标准》识别出65名患者(13%)中总共69种处方用药不当的药物(8种与诊断情况有关[CD],61种与诊断情况无关[ID]),每月成本为824.88欧元,而IPET识别出在有52名患者(10.4%)中存在63种潜在不适当药物,每月成本为381.28欧元。

结论

在初级保健中,相当一部分老年人存在潜在不适当的药物处方情况,具有重大的经济影响。

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