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恢复白三烯 B(4)-12-羟脱氢酶/15-氧代前列腺素 13-还原酶（LTBDH/PGR）的表达可抑制肺癌在体外和体内的生长。

Restoration of leukotriene B(4)-12-hydroxydehydrogenase/15- oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo.

机构信息

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, United States.

出版信息

Lung Cancer. 2010 May;68(2):161-9. doi: 10.1016/j.lungcan.2009.06.011. Epub 2009 Sep 17.

DOI:10.1016/j.lungcan.2009.06.011
PMID:19595472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2847056/
Abstract

Leukotriene B(4)-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase (LTBDH/PGR) is a bifunctional enzyme capable of inactivating leukotriene B(4) (LTB(4)) and 15-oxo-prostaglandins (15-PGs). Its role in growth suppressive functions in lung cancer was studied in in vitro and in vivo systems. The LTBDH/PGR gene was expressed in lung cancer cell lines through recombinant adenovirus infection, and through a tetracycline-inducible expression system. After restoration of LTBDH/PGR expression in LTBDH/PGR-negative (H1299) or -low (A549) lung cancer cell lines, the restored enzyme induced apoptosis and growth inhibition in vitro. Ectopic expression of LTBDH/PGR caused also suppression of tumorigenicity of A549 cells in nude mice. In contrast, LTBDH/PGR over-expression in LTBDH/PGR-positive (H157) lung cancer cell line induced little apoptosis and growth inhibition. This study indicates that restoration of LTBDH/PGR expression is effective in preventing lung cancer growth in vitro and in vivo.

摘要

白三烯 B(4)-12-羟脱氢酶/15-氧前列腺素 13 还原酶（LTBDH/PGR）是一种具有双重功能的酶，能够使白三烯 B(4)（LTB(4)）和 15-氧前列腺素失活。其在肺癌生长抑制功能中的作用已在体外和体内系统中进行了研究。通过重组腺病毒感染和四环素诱导表达系统，LTBDH/PGR 基因在肺癌细胞系中表达。在 LTBDH/PGR 阴性（H1299）或低表达（A549）肺癌细胞系中恢复 LTBDH/PGR 表达后，恢复的酶在体外诱导细胞凋亡和生长抑制。LTBDH/PGR 的异位表达也抑制了裸鼠中 A549 细胞的致瘤性。相比之下，LTBDH/PGR 在 LTBDH/PGR 阳性（H157）肺癌细胞系中的过表达仅引起少量细胞凋亡和生长抑制。本研究表明，恢复 LTBDH/PGR 表达可有效预防肺癌的体外和体内生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5186/2847056/7bde487ad683/nihms126643f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5186/2847056/2594c4b9c687/nihms126643f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5186/2847056/352f60138691/nihms126643f2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5186/2847056/e91f3a5aa0f0/nihms126643f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5186/2847056/1337a8633191/nihms126643f4a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5186/2847056/d3b1dbc29e14/nihms126643f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5186/2847056/7bde487ad683/nihms126643f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5186/2847056/2594c4b9c687/nihms126643f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5186/2847056/352f60138691/nihms126643f2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5186/2847056/e91f3a5aa0f0/nihms126643f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5186/2847056/1337a8633191/nihms126643f4a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5186/2847056/d3b1dbc29e14/nihms126643f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5186/2847056/7bde487ad683/nihms126643f6.jpg

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2
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3
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