阿扑吗啡和氟哌啶醇对黑质-纹状体通路中辣根过氧化物酶躯体向心性转运的影响。

Effects of apomorphine and haloperidol on somatopetal transport of horseradish peroxidase in the nigro-striatal pathway.

作者信息

Divac I, Segal M

机构信息

Laboratory of Behavioral Physiology, Institute of Neurophysiology, University of Copenhagen, Copenhagen Denmark.

出版信息

Neurosci Lett. 1976 Nov;3(4):185-9. doi: 10.1016/0304-3940(76)90071-9.

DOI:10.1016/0304-3940(76)90071-9

PMID:19604884

Abstract

Labeling of cell bodies in pars compacta of substantia nigra (SNc) following injections of horseradish peroxidase (HRP) in the neostriatum was not affected by repeated systemic injections of apomorphine or haloperidol during the survival time. These drugs decelerate and accelerate, respectively, the firing of SNc neurons. Provided the used standard method was sensitive enough, it could be concluded that at least in these neurons the somatopetal transport and accumulation of the tracer do not depend on the rate of electrical activity. Consequently, the intensity of labeling with HRP is not a sensitive index of neuronal activity.

摘要

在新纹状体注射辣根过氧化物酶（HRP）后，黑质致密部（SNc）细胞体的标记不受存活期内重复全身注射阿扑吗啡或氟哌啶醇的影响。这些药物分别使SNc神经元的放电减速和加速。如果所使用的标准方法足够灵敏，那么可以得出结论，至少在这些神经元中，示踪剂向胞体的运输和积累不依赖于电活动速率。因此，HRP标记的强度不是神经元活动的灵敏指标。