Pazos V, Mongrain R, Tardif J C
Department of Mechanical Engineering, McGill University, MacDonald Building, 817 Sherbrooke Street West, Montreal QC H3A 2K6, Canada.
J Mech Behav Biomed Mater. 2009 Oct;2(5):542-9. doi: 10.1016/j.jmbbm.2009.01.003. Epub 2009 Jan 22.
The PVA gels obtained by freezing/thawing cycles of PVA solutions, also called cryogels, exhibit non-linear elastic behavior and can mimic, within certain limits, the behavior of biological soft tissues such as arterial tissue. Several authors have investigated the effects of cryogenic processing parameters on the Young's modulus. However, an elastic modulus does not describe the non-linearity of the cryogel's stress-strain response. This study examines the non-linear elastic response of PVA cryogel under uniaxial tension and investigates how processing parameters such as the concentration, the number of thermal cycles, and the thawing rate affect this response. The relationship between the coefficients of the material model and the processing parameters was interpolated to find the set of parameters that would best approximate the elastic response of healthy porcine coronary arteries under uniaxial tension.
通过聚乙烯醇(PVA)溶液的冻融循环获得的PVA凝胶,也称为冷冻凝胶,表现出非线性弹性行为,并且在一定限度内能够模拟生物软组织(如动脉组织)的行为。几位作者研究了低温处理参数对杨氏模量的影响。然而,弹性模量并不能描述冷冻凝胶应力-应变响应的非线性。本研究考察了PVA冷冻凝胶在单轴拉伸下的非线性弹性响应,并研究了诸如浓度、热循环次数和解冻速率等处理参数如何影响这种响应。对材料模型系数与处理参数之间的关系进行插值,以找到最能近似健康猪冠状动脉在单轴拉伸下弹性响应的参数集。