Dong Zhihong, Li Yubao, Zhang Li, Zou Qin
Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Jun;26(3):545-9.
Through Hydroxyl (-OH) reacting with isocyanate group (-NCO), 13 Wt% nano-hydroxyapatite (n-HA)/polyurethane (PU) composite guided bone regeneration membrane was synthesized by use of solvent evaporation method. Its surface character was analyzed by XRD, IR, TG, contact angle, water absorption, elongation and combustion test and SEM. The results indicate that nano-HA/PU has good homogeneity,the interface between the inorganic mineral and organic polymer is optimized to create proper combination; that n-HA crystals are similar to the apatite crystals in natural bone, HA/PU composite membrane has good hydrophilicity mechanical behavior; and that many pores are observed on the membrane which help cells' metabolism. So the HA/PU composite membrane, thus prepared, has the potential for use in guided bone regeneration and tissue engineering.
通过羟基（-OH）与异氰酸酯基（-NCO）反应，采用溶剂挥发法合成了13重量%的纳米羟基磷灰石（n-HA）/聚氨酯（PU）复合引导骨再生膜。通过X射线衍射（XRD）、红外光谱（IR）、热重分析（TG）、接触角、吸水率、伸长率、燃烧试验以及扫描电子显微镜（SEM）对其表面特性进行了分析。结果表明，纳米-HA/PU具有良好的均匀性，无机矿物与有机聚合物之间的界面得到优化，形成了恰当的结合；n-HA晶体与天然骨中的磷灰石晶体相似，HA/PU复合膜具有良好的亲水性和力学性能；并且在膜上观察到许多孔隙，有助于细胞代谢。因此，如此制备的HA/PU复合膜具有用于引导骨再生和组织工程的潜力。
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