Zaidi M, Moonga B S, Bevis P J, Bascal Z A, Breimer L H
Department of Cellular and Molecular Sciences, St. George's Hospital Medical School, University of London, England.
Crit Rev Clin Lab Sci. 1990;28(2):109-74. doi: 10.3109/10408369009105900.
The calcitonin/CGRP multigene complex encodes a family of peptides: calcitonin, its C-terminal flanking peptide, katacalcin, and a third novel peptide, calcitonin gene-related peptide (CGRP). The 32-amino acid peptide calcitonin inhibits the osteoclast, thereby conserving skeletal mass during periods of potential calcium lack, such as pregnancy, growth, and lactation. This hormonal role is emphasized by observations that lower circulating calcitonin levels are associated with bone loss and that calcitonin replacement prevents further bone loss. Structurally, CGRP resembles calcitonin and has been implicated in neuromodulation and in the physiological regulation of blood flow. Here we review the molecular genetics, structure, and function of the calcitonin-gene peptides as analyzed in the laboratory and focus on more recent clinical studies relating to disorders and therapeutics.
降钙素/CGRP多基因复合体编码一族肽：降钙素、其C末端侧翼肽、降钙素原，以及第三种新肽，降钙素基因相关肽（CGRP）。32个氨基酸的肽降钙素可抑制破骨细胞，从而在潜在钙缺乏时期（如妊娠、生长和哺乳期）维持骨骼质量。循环降钙素水平降低与骨质流失相关，而降钙素替代可防止进一步骨质流失，这些观察结果强调了这种激素作用。在结构上，CGRP类似于降钙素，并与神经调节和血流的生理调节有关。在此，我们综述了实验室分析的降钙素基因肽的分子遗传学、结构和功能，并重点关注与疾病和治疗相关的最新临床研究。
