State Institute of Diabetes and Endocrinology, IEDE, Rio de Janeiro, Brazil.
J Endocrinol Invest. 2010 Jun;33(6):382-7. doi: 10.1007/BF03346608. Epub 2009 Jul 28.
Insulin resistance (IR) is associated with intramyocellular lipid (IMCL) content and low serum adiponectin (ADP) levels and ADP is also involved in muscle fat oxidation. However, the relationship between ADP and IMCL content is still controversial and in this study we explored it further in non-diabetic adults.
Cross-sectional clinical study.
Thirty-three adult subjects, 24 obese non-diabetic patients with metabolic syndrome (MS) and 9 lean healthy controls.
Proton nuclear magnetic resonance spectroscopy (1H-NMRS) was performed to quantify IMCL content. The latter plus serum ADP, anthropometrics and biochemical parameters were evaluated and compared in these 2 groups.
MS patients had higher body mass index, waist, waist-to- hip ratio, glucose, insulin, and triglycerides and lower HDL cholesterol (HDLc) compared to controls. Homeostasis model assessment of IR (HOMA-IR) [3.25 (2.58-4.13) vs 1.02 (0.73- 1.29); p<0.0001] and IMCL content [266.1 (189.9-296.3) vs 72.85 (55.3-109.4) AU, p<0.0001] were higher, and quantitative insulin-sensitivity check index (QUICKI) [0.32 (0.31-0.33) vs 0.38 (0.37-0.40); p<0.0001] and ADP [8.6 (4.05-15.95) vs 21.1 (12.9- 24.4) microg/ml; p=0.02] were lower in MS subjects compared to controls. IMCL content was directly associated to glucose, insulin, triglycerides, and HOMA-IR and inversely to HDLc, QUICKI and, more importantly, to ADP (r=-0.41; p<0.05). Only in the MS group, ADP partially influenced IMCL content.
ADP is inversely related to IMCL content in non-diabetic adults. This finding has possible implications for the role of ADP in muscle fat oxidation, IR, and MS.
胰岛素抵抗（IR）与肌内脂质（IMCL）含量和血清脂联素（ADP）水平降低有关，而 ADP 也参与肌肉脂肪氧化。然而，ADP 与 IMCL 含量之间的关系仍存在争议，本研究旨在进一步探讨非糖尿病成年人中的这种关系。
横断面临床研究。
33 名成年受试者，24 名患有代谢综合征（MS）的肥胖非糖尿病患者和 9 名瘦健康对照者。
采用质子磁共振波谱（1H-NMR）法测定 IMCL 含量。比较并评估这两组的 IMCL 含量以及血清 ADP、人体测量学和生化参数。
与对照组相比，MS 患者的体重指数、腰围、腰臀比、血糖、胰岛素和甘油三酯更高，而高密度脂蛋白胆固醇（HDLc）更低。IR 的稳态模型评估（HOMA-IR）[3.25（2.58-4.13）比 1.02（0.73-1.29）；p<0.0001]和 IMCL 含量[266.1（189.9-296.3）比 72.85（55.3-109.4）AU，p<0.0001]更高，而定量胰岛素敏感性检查指数（QUICKI）[0.32（0.31-0.33）比 0.38（0.37-0.40）；p<0.0001]和 ADP[8.6（4.05-15.95）比 21.1（12.9-24.4）μg/ml；p=0.02]更低。与对照组相比，MS 患者的 IMCL 含量与血糖、胰岛素、甘油三酯和 HOMA-IR 呈正相关，与 HDLc、QUICKI 和更重要的 ADP 呈负相关（r=-0.41；p<0.05）。仅在 MS 组中，ADP 部分影响 IMCL 含量。
在非糖尿病成年人中，ADP 与 IMCL 含量呈负相关。这一发现可能表明 ADP 在肌肉脂肪氧化、IR 和 MS 中的作用。
