库拉索芦荟中新的三糖基萘苷

A new triglucosylated naphthalene glycoside from Aloe vera L.

机构信息

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education and Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.

出版信息

Fitoterapia. 2010 Jan;81(1):59-62. doi: 10.1016/j.fitote.2009.07.006. Epub 2009 Jul 26.

DOI:10.1016/j.fitote.2009.07.006

PMID:19638305

Abstract

A new triglucosylated naphthalene derivative, named aloveroside A (1), together with two known anthraquinone dimers and two 6-phenyl-2-pyrone derivatives, was isolated from the Aloe vera ethanolic extracts. The structure of 1 was established as 1-(((4-(1-O-beta-D-glucopyranosyl -(1-->4)-beta-D-xylopyranoside)-hydroxymethyl)-1-hydroxy-8-O-alpha-L-rhamnopyranoside)naphthalene-2-yl)-ethanone by means of spectroscopic evidences and chemical methods. All these compounds were tested for their BACE inhibitory activity but no significant activities were found.

摘要

从库拉索芦荟乙醇提取物中分离得到一种新的三葡糖苷萘衍生物，命名为芦荟苷 A（1），以及两种已知的蒽醌二聚体和两种 6-苯基-2-吡喃酮衍生物。通过光谱证据和化学方法，确定 1 的结构为 1-(((4-(1-O-β-D-吡喃葡萄糖基-(1-->4)-β-D-吡喃木糖基)-羟甲基)-1-羟基-8-O-α-L-鼠李吡喃糖苷基)萘-2-基)-乙酮。所有这些化合物都进行了 BACE 抑制活性测试，但没有发现显著的活性。