Rychlik A, Nieradka R, Kander M, Depta A
University of Warmia and Mazury in Olsztyn, Faculty of Veterinary Medicine, Department of Clinical Diagnostics Oczapowskiego 14, Olsztyn-Kortowo, Poland.
Pol J Vet Sci. 2009;12(2):217-23.
The objective of this study was to carry out a macroscopic and histopathological examination of the gastric mucosa in dogs with inflammatory bowel disease and to evaluate the effect of mesalazine therapy on histopathological changes in the gastric mucosa. The treatment was performed on 18 dogs with histopathologically confirmed inflammation of the duodenum and the jejunum. The animals were administered mesalazine at 12.5 mg/kg b.w. bid over a six-week period. The dogs investigated were diagnosed with chronic catarrhal gastritis with intense lymphocytic/plasmocytic infiltration. In 83% of the dogs, intestinal metaplasia had been noted in bioptates before examination. The results of macroscopic and microscopic examinations revealed that the applied treatment had a positive effect on gastric mucosal morphology. Cellular infiltration of the gastric mucosa was significantly inhibited, most probably, due to the anti-inflammatory effect of mesalazine.
本研究的目的是对患有炎症性肠病的犬胃黏膜进行宏观和组织病理学检查，并评估美沙拉嗪治疗对胃黏膜组织病理学变化的影响。对18只经组织病理学证实患有十二指肠和空肠炎的犬进行治疗。在六周的时间里，给这些动物按体重12.5mg/kg每日两次服用美沙拉嗪。所研究的犬被诊断为伴有强烈淋巴细胞/浆细胞浸润的慢性卡他性胃炎。在83%的犬中，检查前活检组织中已发现肠化生。宏观和微观检查结果显示，所应用的治疗对胃黏膜形态有积极影响。胃黏膜的细胞浸润明显受到抑制，这很可能是由于美沙拉嗪的抗炎作用。
