Margalit Nevo, Wasserzug Oshri, De-Row Ari, Abergel Avraham, Fliss Dan M, Gil Ziv
Skull Base Surgery Service, Tel-Aviv University, Tel-Aviv, Israel.
J Neurosurg Pediatr. 2009 Aug;4(2):113-7. doi: 10.3171/2009.4.PEDS08321.
The purpose of this study was to describe the surgical treatment and outcomes of patients with intracranial extension of juvenile nasopharyngeal angiofibroma (JNA).
Twenty-one patients who underwent operations for JNAs between 1994 and 2008 were enrolled in the study. Seven patients (33%) had intracranial tumor extension. The middle cranial fossa and cavernous sinus were involved in 4 patients who underwent operations via the combined infratemporal fossa-midfacial degloving approach. The anterior skull base was involved in 3 patients who underwent the subcranialmidfacial degloving approach.
Complete tumor removal was achieved in all patients. Postoperative complications included 1 case of soft-tissue infection. None of the patients had tumor recurrence after a mean follow-up of 42 months (range 29-85 months). No adjuvant therapy was required in any patient.
Combined approaches can be used effectively for treatment of JNAs with intracranial extension without the need for adjuvant therapy.
本研究旨在描述青少年鼻咽血管纤维瘤（JNA）颅内扩展患者的手术治疗及结果。
纳入1994年至2008年间接受JNA手术的21例患者。7例（33%）有颅内肿瘤扩展。4例经颞下窝 - 面中部联合掀翻入路手术的患者中颅窝和海绵窦受累。3例经颅面中部掀翻入路手术的患者前颅底受累。
所有患者均实现肿瘤完全切除。术后并发症包括1例软组织感染。平均随访42个月（范围29 - 85个月），无患者出现肿瘤复发。无需对任何患者进行辅助治疗。
联合入路可有效用于治疗颅内扩展的JNA，无需辅助治疗。
