Storz G, Tartaglia L A, Farr S B, Ames B N
Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892.
Trends Genet. 1990 Nov;6(11):363-8. doi: 10.1016/0168-9525(90)90278-e.
Bacteria treated with low doses of oxidants such as hydrogen peroxide adapt to subsequent high doses of these oxidants by inducing the expression of numerous genes. The study of these genes and the roles they play in defending bacteria against oxidative damage has given general insights into what oxidants are hazardous to cells, what cell constituents are damaged by oxidants, and how cells sense and respond to oxidative stress.
用低剂量氧化剂（如过氧化氢）处理的细菌，通过诱导众多基因的表达，适应随后的高剂量这些氧化剂。对这些基因及其在保护细菌免受氧化损伤中所起作用的研究，已使人们对哪些氧化剂对细胞有害、哪些细胞成分会被氧化剂破坏，以及细胞如何感知和应对氧化应激有了总体认识。
