在冠心病患者中，系统性高血压会增强乳腺动脉中内皮素A受体的表达，而胰岛素依赖型糖尿病则会下调该受体的表达。

Systemic hypertension augments, whereas insulin-dependent diabetes down-regulates, endothelin A receptor expression in the mammary artery in coronary artery disease patients.

作者信息

Zygalaki Eleni, Kaklamanis Loukas, Lolaka Maria, Nikolaou Nikolaos, Koutouzis Michael, Lianidou Evi S, Kyriakides Zenon S

机构信息

Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Greece.

出版信息

Cardiol J. 2009;16(4):348-54.

PMID:19653178

Abstract

BACKGROUND

Endothelin (ET) A receptor antagonism causes decreased vasodilation in hypertensive coronary arteries and decreased effects on coronary artery compliance in diabetic patients.

METHODS

We investigate the mRNA expression of ET-1, ET(A) and ET(B) receptors, using real time RT-PCR, in biopsies from the internal mammary artery obtained from 49 patients, 18 diabetics and 34 hypertensives, all undergoing coronary artery bypass grafting.

RESULTS

Hypertensive patients had higher ET-1 mRNA expression (16438 [8417, 23917]), than normotensive patients (2974 [2283, 18055], p=0.008). Diabetic patients had significantly lower ET(A) receptor levels than non-diabetic patients (455 [167, 1496] vs. 1660 [700, 3190], respectively, p = 0.003).

CONCLUSIONS

Multivariate analysis demonstrated that the presence of systemic hypertension was the only independent predictor of log ET(A) receptor expression and log ET-1 expression, while insulin-dependent diabetes was negatively correlated with ET(A) receptor expression. ETB receptor expression was not correlated with any predictor. Systemic hypertension is associated with increased ET-1 and ET(A) receptor mRNA expression, whereas insulin-dependent diabetes down-regulates ET(A) receptor mRNA expression in the internal mammary artery in patients with coronary artery disease undergoing bypass grafting.

摘要

背景

内皮素（ET）A 受体拮抗作用会导致高血压患者冠状动脉血管舒张功能降低，以及糖尿病患者冠状动脉顺应性降低。

方法

我们采用实时逆转录聚合酶链反应（RT-PCR），对 49 例患者（18 例糖尿病患者和 34 例高血压患者）行冠状动脉搭桥术时获取的乳内动脉活检组织中 ET-1、ET(A)和 ET(B)受体的 mRNA 表达进行了研究。

结果

高血压患者的 ET-1 mRNA 表达水平（16438 [8417, 23917]）高于血压正常患者（2974 [2283, 18055]，p = 0.008）。糖尿病患者的 ET(A)受体水平显著低于非糖尿病患者（分别为 455 [167, 1496] 和 1660 [700, 3190]，p = 0.003）。

结论

多变量分析表明，系统性高血压是 log ET(A)受体表达和 log ET-1 表达的唯一独立预测因素，而胰岛素依赖型糖尿病与 ET(A)受体表达呈负相关。ETB 受体表达与任何预测因素均无相关性。系统性高血压与 ET-1 和 ET(A)受体 mRNA 表达增加有关，而胰岛素依赖型糖尿病会使行冠状动脉搭桥术的冠心病患者乳内动脉中的 ET(A)受体 mRNA 表达下调。